Gabapentin enacarbil
CAS No. 478296-72-9
Gabapentin enacarbil ( XP-13512 )
Catalog No. M26692 CAS No. 478296-72-9
Gabapentin enacarbil is a prodrug for the anticonvulsant and analgesic drug gabapentin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 162 | Get Quote |
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10MG | 267 | Get Quote |
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25MG | 436 | Get Quote |
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50MG | 653 | Get Quote |
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100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameGabapentin enacarbil
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NoteResearch use only, not for human use.
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Brief DescriptionGabapentin enacarbil is a prodrug for the anticonvulsant and analgesic drug gabapentin.
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DescriptionGabapentin enacarbil is a prodrug for the anticonvulsant and analgesic drug gabapentin. Gabapentin enacarbil provides sustained dose-proportional exposure to gabapentin and predictable bioavailability. (In Vitro):Gabapentin enacarbil demonstrated active apical to basolateral transport across Caco-2 cell monolayers and pH-dependent passive permeability across artificial membranes. XP13512 inhibited uptake of (14)C-lactate by human embryonic kidney cells expressing monocarboxylate transporter type-1, and direct uptake of prodrug by these cells was confirmed using liquid chromatography-tandem mass spectrometry. XP13512 inhibited uptake of (3)H-biotin into Chinese hamster ovary cells overexpressing human sodium-dependent multivitamin transporter (SMVT) . (In Vivo):In 4 studies of healthy volunteers (136 subjects total), the pharmacokinetics of Gabapentin enacarbil immediate- and extended-release formulations were compared with those of oral gabapentin. Gabapentin enacarbil immediate-release (up to 2800 mg single dose and 2100 mg twice daily) was well absorbed (>68%, based on urinary recovery of gabapentin), converted rapidly to gabapentin, and provided dose-proportional exposure, whereas absorption of oral gabapentin declined with increasing doses to <27% at 1200 mg. Compared with 600 mg gabapentin, an equimolar Gabapentin enacarbil extended-release dose provided extended gabapentin exposure (time to maximum concentration, 8.4 vs 2.7 hours) and superior bioavailability (74.5% vs 36.6%) .
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SynonymsXP-13512
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number478296-72-9
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Formula Weight329.4
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Molecular FormulaC16H27NO6
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)C(=O)OC(C)OC(=O)NCC1(CC(O)=O)CCCCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lingxiao Zhang, et al. Synthetic method of 3',5' -dichloro-2, 2, 2-trifluoro acetophenone derivative. CN113024390A
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